Breast Cancer
Radiation Oncology - Principles, Precepts and Practice, Springer International Publishing Ag, ss.153-206, 2026
- Yayın Türü: Kitapta Bölüm / Araştırma Kitabı
- Basım Tarihi: 2026
- Doi Numarası: 10.1007/978-981-95-5171-2_5
- Yayınevi: Springer International Publishing Ag
- Sayfa Sayıları: ss.153-206
- Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Evet
Özet
Breast cancer is the most frequently diagnosed malignancy among women globally and remains a major contributor to cancer-related mortality. Over recent decades, survival outcomes have improved substantially due to advances in multimodal treatment strategies, including surgery, systemic therapies, and radiation therapy. Radiation therapy constitutes a cornerstone of breast cancer management across all disease stages, ranging from early-stage disease treated with breast-conserving approaches to locally advanced and metastatic cases. This chapter presents a comprehensive overview of the biological basis, clinical indications, and technological developments in radiation therapy for breast cancer. Major areas of focus include adjuvant radiotherapy following breast-conserving surgery and mastectomy, regional nodal irradiation, hypofractionated treatment regimens, partial breast irradiation, and the integration of radiation therapy with systemic treatments such as chemotherapy, endocrine therapy, and targeted agents. Emerging modalities, including intensity-modulated and image-guided radiation therapy, are examined for their potential to enhance tumor control while reducing radiation exposure to surrounding normal tissues. Furthermore, the chapter discusses acute and late radiation-induced toxicities, quality-of-life implications, and ongoing challenges in treatment individualization. By integrating findings from landmark clinical trials and contemporary studies, this chapter underscores the evolving role of radiation therapy in breast cancer care and highlights future directions aimed at improving therapeutic outcomes and patient-centered management.