NY-ESO-1: Review of an immunogenic tumor antigen

Gnjatic S., Nishikawa H., Jungbluth A. A., Guere A. O., Ritter G., Jaeger E., ...More

ADVANCES IN CANCER RESEARCH, VOL 95, vol.95, pp.1-30, 2006 (SCI-Expanded) identifier identifier identifier


In the 9 years since its discovery, cancer-testis antigen NY-ESO-1 has made one of the fastest transitions from molecular, cellular, and immunological description to vaccine and immunotherapy candidate, already tested in various formulations in more than 30 clinical trials worldwide. Its main characteristic resides in its capacity to elicit spontaneous antibody and T-cell responses in a proportion of cancer patients. An overview of immunological findings and immunotherapeutic approaches with NY-ESO-1, as well the role of regulation in NY-ESO-1 immunogenicity, is presented here. (c) 2006 Elsevier Inc.