NY-ESO-1: Review of an immunogenic tumor antigen

Gnjatic S., Nishikawa H., Jungbluth A. A., Guere A. O., Ritter G., Jaeger E., ...Daha Fazla

ADVANCES IN CANCER RESEARCH, VOL 95, cilt.95, ss.1-30, 2006 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 95
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1016/s0065-230x(06)95001-5
  • Dergi Adı: ADVANCES IN CANCER RESEARCH, VOL 95
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1-30
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Hayır

Özet

In the 9 years since its discovery, cancer-testis antigen NY-ESO-1 has made one of the fastest transitions from molecular, cellular, and immunological description to vaccine and immunotherapy candidate, already tested in various formulations in more than 30 clinical trials worldwide. Its main characteristic resides in its capacity to elicit spontaneous antibody and T-cell responses in a proportion of cancer patients. An overview of immunological findings and immunotherapeutic approaches with NY-ESO-1, as well the role of regulation in NY-ESO-1 immunogenicity, is presented here. (c) 2006 Elsevier Inc.