A prospective, randomized, double-blind, placebo-controlled trial of glyceryl-trinitrate ointment in the treatment of children with anal fissure

Tander B., Guven A., Demirbag S., Ozkan Y., Ozturk H., Cetinkursun S.

JOURNAL OF PEDIATRIC SURGERY, cilt.34, sa.12, ss.1810-1812, 1999 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 34 Sayı: 12
  • Basım Tarihi: 1999
  • Doi Numarası: 10.1016/s0022-3468(99)90318-4
  • Dergi Adı: JOURNAL OF PEDIATRIC SURGERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1810-1812
  • Anahtar Kelimeler: anal fissure, nitric oxide, glyceryl trinitrate, NITRIC-OXIDE, SPHINCTEROTOMY, NITROGLYCERIN, CYCLASE
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Hayır

Özet

Background: Anal fissure in children usually is treated by sitz baths, stool softeners, and analgesic ointments. However, some cases are intractable to the treatment. In recent years, it has been reported that nitric oxide donors such as local glyceryl-trinitrate (GTN) ointment causes a reversible chemical sphincterotomy. Although the GTN ointment can be an alternative therapy for adult cases, it has not yet been studied in the children who suffer from anal fissure.