A prospective, randomized, double-blind, placebo-controlled trial of glyceryl-trinitrate ointment in the treatment of children with anal fissure

Tander B., Guven A., Demirbag S., Ozkan Y., Ozturk H., Cetinkursun S.

JOURNAL OF PEDIATRIC SURGERY, vol.34, no.12, pp.1810-1812, 1999 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 34 Issue: 12
  • Publication Date: 1999
  • Doi Number: 10.1016/s0022-3468(99)90318-4
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED)
  • Page Numbers: pp.1810-1812
  • Keywords: anal fissure, nitric oxide, glyceryl trinitrate, NITRIC-OXIDE, SPHINCTEROTOMY, NITROGLYCERIN, CYCLASE
  • Acibadem Mehmet Ali Aydinlar University Affiliated: Yes


Background: Anal fissure in children usually is treated by sitz baths, stool softeners, and analgesic ointments. However, some cases are intractable to the treatment. In recent years, it has been reported that nitric oxide donors such as local glyceryl-trinitrate (GTN) ointment causes a reversible chemical sphincterotomy. Although the GTN ointment can be an alternative therapy for adult cases, it has not yet been studied in the children who suffer from anal fissure.