A prospective, randomized, double-blind, placebo-controlled trial of glyceryl-trinitrate ointment in the treatment of children with anal fissure

Tander B. , Guven A., Demirbag S., Ozkan Y., Ozturk H., Cetinkursun S.

JOURNAL OF PEDIATRIC SURGERY, cilt.34, sa.12, ss.1810-1812, 1999 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 34 Konu: 12
  • Basım Tarihi: 1999
  • Doi Numarası: 10.1016/s0022-3468(99)90318-4
  • Sayfa Sayıları: ss.1810-1812


Background: Anal fissure in children usually is treated by sitz baths, stool softeners, and analgesic ointments. However, some cases are intractable to the treatment. In recent years, it has been reported that nitric oxide donors such as local glyceryl-trinitrate (GTN) ointment causes a reversible chemical sphincterotomy. Although the GTN ointment can be an alternative therapy for adult cases, it has not yet been studied in the children who suffer from anal fissure.