IL-1 beta is induced in reactive astrocytes in the somatosensory cortex of rats with genetic absence epilepsy at the onset of spike-and-wave discharges, and contributes to their occurrence


Akin D., Ravizza T., Maroso M., ÇARÇAK YILMAZ N., Eryigit T., Vanzulli I., ...More

NEUROBIOLOGY OF DISEASE, vol.44, no.3, pp.259-269, 2011 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 44 Issue: 3
  • Publication Date: 2011
  • Doi Number: 10.1016/j.nbd.2011.05.015
  • Title of Journal : NEUROBIOLOGY OF DISEASE
  • Page Numbers: pp.259-269

Abstract

Interleukin (IL)-1 beta plays a crucial role in the mechanisms of limbic seizures in rodent models of temporal lobe epilepsy. We addressed whether activation of the IL-1 beta signaling occurs in rats with genetic absence epilepsy (GAERS) during the development of spike-and-wave discharges (SWDs). Moreover, we studied whether inhibition of IL-1 beta biosynthesis in GAERS could affect SWD activity.