IL-1 beta is induced in reactive astrocytes in the somatosensory cortex of rats with genetic absence epilepsy at the onset of spike-and-wave discharges, and contributes to their occurrence

Akin, Demet; Ravizza, Teresa; Maroso, Mattia; ÇARÇAK YILMAZ, Nihan; Eryigit, Tugba; Vanzulli, Ilaria; GÜLHAN, REZZAN; Vezzani, Annamaria; Onat, FILIZ

doi:10.1016/j.nbd.2011.05.015

IL-1 beta is induced in reactive astrocytes in the somatosensory cortex of rats with genetic absence epilepsy at the onset of spike-and-wave discharges, and contributes to their occurrence

Atıf İçin Kopyala

Akin D., Ravizza T., Maroso M., ÇARÇAK YILMAZ N., Eryigit T., Vanzulli I., ...Daha Fazla

NEUROBIOLOGY OF DISEASE, cilt.44, sa.3, ss.259-269, 2011 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 44 Sayı: 3
Basım Tarihi: 2011
Doi Numarası: 10.1016/j.nbd.2011.05.015
Dergi Adı: NEUROBIOLOGY OF DISEASE
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.259-269
Anahtar Kelimeler: Inflammation, Absence seizures, Interleukins, SWD, EXPERIMENTAL FEBRILE SEIZURES, STATUS EPILEPTICUS, GLUTAMATE UPTAKE, EPILEPTOGENESIS, EXPRESSION, MODEL, ACTIVATION, INTERLEUKIN-1-BETA, HIPPOCAMPUS, CYTOKINES
Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Hayır

Özet

Interleukin (IL)-1 beta plays a crucial role in the mechanisms of limbic seizures in rodent models of temporal lobe epilepsy. We addressed whether activation of the IL-1 beta signaling occurs in rats with genetic absence epilepsy (GAERS) during the development of spike-and-wave discharges (SWDs). Moreover, we studied whether inhibition of IL-1 beta biosynthesis in GAERS could affect SWD activity.