Treatment and follow-up results of WHO grade II meningiomas

GUDUK M., Eksi M. S., BOZKURT B., USSELİ M. İ., ERŞEN DANYELİ A., Pamir M. N.

JOURNAL OF CLINICAL NEUROSCIENCE, cilt.91, ss.354-364, 2021 (SCI-Expanded) identifier identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 91
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1016/j.jocn.2021.07.022
  • Dergi Adı: JOURNAL OF CLINICAL NEUROSCIENCE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.354-364
  • Anahtar Kelimeler: Meningiomas, Grade II meningiomas, Atypical meningiomas, Chordoid meningiomas, Clear cell meningiomas, PROGRESSION-FREE SURVIVAL, ATYPICAL CRANIAL MENINGIOMAS, CENTRAL-NERVOUS-SYSTEM, GROSS TOTAL RESECTION, ANAPLASTIC MENINGIOMAS, PROGNOSTIC-FACTORS, INTRACRANIAL MENINGIOMAS, MALIGNANT MENINGIOMAS, ADJUVANT RADIATION, CLINICAL-SERIES
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Evet

Özet

Meningiomas are the most common primary intracranial tumors. They have three pathologic grades. Surgical resection aiming Simpson I resection is the standard treatment for meningiomas. Radiotherapy and Gamma Knife radiosurgery are the main adjuvant and salvage treatments. Chemotherapy has limited use. Grade II, and III meningiomas have a higher recurrence rate, and adjuvant radiotherapy is usually the standard treatment for grade III meningiomas but there is not a consensus regarding grade II meningiomas. In this paper, we analyzed our meningioma series of 1401 patients and presented the treatment and follow-up results of 170 grade II meningioma cases. The median follow-up of grade II meningiomas was 61 (range = 1-231) months. The mean age of patients was 52. 5 +/- 15.0 years, 102 of them were female and 68 were male (female/male ratio = 1.5). The median progression-free survival (PFS) of them was 109 months, and the cumulative overall survival (OS) rate was 85% at 10 years. Meningiomas with gross total resection, non-skull base meningiomas, and primary grade II meningiomas had longer PFS with statistical significance, while non-skull base meningiomas, younger group of patients, and primary grade II meningiomas had longer OS with a statistical significance. (c) 2021 Elsevier Ltd. All rights reserved.