Arg25Pro (c.915G > C) polymorphism of transforming growth factor beta 1 gene suggests an association with increased risk for Hashimoto's thyroiditis

Vural P., Degirmencioglu S., Dogru-Abbasoglu S., Baki M., Ozderya A., Karadag B. , ...Daha Fazla

INTERNATIONAL IMMUNOPHARMACOLOGY, cilt.28, ss.521-524, 2015 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 28 Konu: 1
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1016/j.intimp.2015.07.019
  • Sayfa Sayıları: ss.521-524


Background: The etiopathogenesis of Hashimoto's thyroiditis (HT) - has not been clearly elucidated although the role of chronic inflammation, endothelial dysfunction, and imbalance between pro- and anti-inflammatory cytokines has been established. Transforming growth factor beta 1 (TGF beta 1) is required to maintain immune homeostasis, and is implicated in lymphocyte infiltration, production of autoantibodies and thyrocyte destruction seen in patients with HT.