Arg25Pro (c.915G > C) polymorphism of transforming growth factor beta 1 gene suggests an association with increased risk for Hashimoto's thyroiditis

Vural, Pervin; Degirmencioglu, Sevgin; Dogru-Abbasoglu, Semra; Baki, Merve; Ozderya, Aysenur; Karadag, Berrin; Uysal, Mujdat

doi:10.1016/j.intimp.2015.07.019

Arg25Pro (c.915G > C) polymorphism of transforming growth factor beta 1 gene suggests an association with increased risk for Hashimoto's thyroiditis

Atıf İçin Kopyala

Vural P., Degirmencioglu S., Dogru-Abbasoglu S., Baki M., Ozderya A., Karadag B. , et al.

INTERNATIONAL IMMUNOPHARMACOLOGY, cilt.28, ss.521-524, 2015 (SCI İndekslerine Giren Dergi)

Cilt numarası: 28 Konu: 1
Basım Tarihi: 2015
Doi Numarası: 10.1016/j.intimp.2015.07.019
Dergi Adı: INTERNATIONAL IMMUNOPHARMACOLOGY
Sayfa Sayısı: ss.521-524

Özet

Background: The etiopathogenesis of Hashimoto's thyroiditis (HT) - has not been clearly elucidated although the role of chronic inflammation, endothelial dysfunction, and imbalance between pro- and anti-inflammatory cytokines has been established. Transforming growth factor beta 1 (TGF beta 1) is required to maintain immune homeostasis, and is implicated in lymphocyte infiltration, production of autoantibodies and thyrocyte destruction seen in patients with HT.