Arg25Pro (c.915G > C) polymorphism of transforming growth factor beta 1 gene suggests an association with increased risk for Hashimoto's thyroiditis


Vural P., Degirmencioglu S., Dogru-Abbasoglu S., Baki M., Ozderya A., Karadag B. , ...More

INTERNATIONAL IMMUNOPHARMACOLOGY, vol.28, no.1, pp.521-524, 2015 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 28 Issue: 1
  • Publication Date: 2015
  • Doi Number: 10.1016/j.intimp.2015.07.019
  • Title of Journal : INTERNATIONAL IMMUNOPHARMACOLOGY
  • Page Numbers: pp.521-524

Abstract

Background: The etiopathogenesis of Hashimoto's thyroiditis (HT) - has not been clearly elucidated although the role of chronic inflammation, endothelial dysfunction, and imbalance between pro- and anti-inflammatory cytokines has been established. Transforming growth factor beta 1 (TGF beta 1) is required to maintain immune homeostasis, and is implicated in lymphocyte infiltration, production of autoantibodies and thyrocyte destruction seen in patients with HT.