Plasma thiopurine S-methyltransferase levels and azathioprine-related adverse events in patients with Behcet's disease


Emmungil H., DURUSOY ONMUŞ İ. R. , Kalfa M., Zihni F. Y. , Ozmen M., Keser G., ...Daha Fazla

CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, cilt.33, 2015 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 33 Konu: 6
  • Basım Tarihi: 2015
  • Dergi Adı: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY

Özet

Objective. Thiopurine S-methyltransferase (TPMT) is the key enzyme inactivating azathioprine (AZA), an immunosuppressive agent commonly used for treating inflammatory diseases including Behcet's disease (BD), systemic lupus erythematosus (SLE) and systemic vasculitis. Low TPMT levels facilitate occurrence of AZA-related adverse effects. We investigated TPMT levels in patients with BD, compared to healthy controls and patients with SLE or systemic vasculitis.