Label-Free Biosensors for the Detection and Quantification of Cardiovascular Risk Markers

Saravan K. S., Gul O., Basaga H., Sezerman U., Gurbuz Y.

SENSOR LETTERS, cilt.6, sa.6, ss.873-877, 2008 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 6 Sayı: 6
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1166/sl.2008.521
  • Dergi Adı: SENSOR LETTERS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED)
  • Sayfa Sayıları: ss.873-877
  • Anahtar Kelimeler: Biosensor, Antibody, Capacitive, Cardiovascular, C-Reactive Protein, C-REACTIVE PROTEIN
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Hayır

Özet

This paper presents a biosensor implementation for the detection of protein molecules using specific antibodies. Affinity sensors allow the detection and quantification of target molecules in complex mixtures by affinity-based interactions. Immobilized antibody molecules are the probes that bind to specific protein molecules (targets) in biological fluids. In this study, inter-digitated electrodes in the form of capacitance on glass slide were designed, fabricated and used to measure the changes in the dielectric properties of the inter-digitated capacitances. Our results in this study present that with a careful design of micro-interdigitated capacitors, a wider dynamic range and higher sensitivity can be achieved for the detection and quantification of C-Reactive Protein.