Muscarinic receptor mediated cAMP response in human K562 chronic myelogenous leukemia cells

Cabadak H., Aydın B., Kan B.

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, vol.36, pp.188-192, 2011 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 36
  • Publication Date: 2011
  • Journal Name: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.188-192
  • Acibadem Mehmet Ali Aydinlar University Affiliated: Yes

Abstract

Objectives: Muscarinic acetylcholine receptors play key roles in regulating many diverse physiological processes. Recent studies suggest that muscarinic receptors mediate some cellular events in hematopoietic cells. Muscarinic receptors are expressed in different human cells. cAMP an intracellular signaling molecule, is involved in a wide variety of physiological functions and stimulation of muscarinic receptors leads to the alteration of intracellular cAMP levels. The present study investigated muscarinic receptors mediated cAMP level in K562 chronic myelogenous leukemic cells.