8-Hydroxydeoxyguanosine as a Useful Marker for Determining the Severity of Trichloroethylene Exposure


Abusoglu S., Celik H. T. , Tutkun E., Yilmaz H., Serdar M. A. , Bal C. D. , ...More

ARCHIVES OF ENVIRONMENTAL & OCCUPATIONAL HEALTH, vol.69, no.3, pp.180-186, 2014 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 69 Issue: 3
  • Publication Date: 2014
  • Doi Number: 10.1080/19338244.2013.763761
  • Title of Journal : ARCHIVES OF ENVIRONMENTAL & OCCUPATIONAL HEALTH
  • Page Numbers: pp.180-186

Abstract

The aim of this study was to determine 8-hydroxydeoxyguanosine (8-OH-dG) levels in trichloroethylene (TCE)-exposed workers. Oxidative stress biomarkers and biochemical parameters were monitored among 26 TCE-exposed workers and 78 age-matched control subjects. Levels of urinary 8-OH-dG were analyzed by liquid chromatography tandem mass spectrometry. Urinary 8-OH-dG levels were significantly higher for TCE-exposed group (p < .001). Spearman's correlation test revealed positive correlations between urinary trichloroacetic acid levels and age, urinary 8-OH-dG, urinary total oxidant status, and urinary total antioxidant status (p = .042, p < .001, p < .001, and p < .001, respectively). 8-OH-dG may be a useful marker to determine the extent of TCE exposure.