Halofuginone has a Beneficial Effect on Gentamicin-induced Acute Nephrotoxicity in Rats

Karakoyun B., YÜKSEL M., Turan P., Arbak S., Alican I.

DRUG AND CHEMICAL TOXICOLOGY, cilt.32, sa.4, ss.312-318, 2009 (SCI-Expanded) identifier identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 32 Sayı: 4
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1080/01480540902976911
  • Dergi Adı: DRUG AND CHEMICAL TOXICOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.312-318
  • Anahtar Kelimeler: Gentamicin, halofuginone, nephrotoxicity, VERSUS-HOST-DISEASE, ACUTE-RENAL-FAILURE, COLLAGEN-SYNTHESIS, I SYNTHESIS, LIPID-PEROXIDATION, CELL-PROLIFERATION, FREE-RADICALS, INHIBITION, CARCINOMA, FIBROSIS
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Hayır

Özet

The aim of this study was to investigate the putative beneficial effect of halofuginone on gentamicin-induced nephrotoxicity in rats. Sprague-Dawley rats were treated with gentamicin sulphate (GEN; 80 mg/kg) or saline intraperitoneally (i.p.) for 7 days. Halofuginone was administered (0.1 mg/kg/day; i.p.) following GEN or saline injections. Blood and urine samples were collected to measure the renal function tests. Kidneys were excised for histological evaluation and for the measurement of malondialdehyde (MDA), glutathione (GSH), myeloperoxidase (MPO) activity, and chemiluminescence (CL). Halofuginone treatment to animals with GEN-induced renal injury caused a significant decrease in serum blood urea nitrogen level and reduced the elevated MDA, GSH content, and MPO activity. It was also effective in reversing the elevated CL values of rats with GEN-induced nephrotoxicity and preserving renal morphology, as examined microscopically. In conclusion, halofuginone was beneficial in GEN-induced acute nephrotoxicity. The mechanism could be attributed, at least in part, to decreased tissue leukocyte infiltration and reactive metabolite production.