Components of ambient air pollution affect thrombin generation in healthy humans: the RAPTES project


Strak M., Hoek G., Steenhof M., Kilinc E. , Godri K. J. , Gosens I., ...More

OCCUPATIONAL AND ENVIRONMENTAL MEDICINE, vol.70, no.5, pp.332-340, 2013 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 70 Issue: 5
  • Publication Date: 2013
  • Doi Number: 10.1136/oemed-2012-100992
  • Title of Journal : OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
  • Page Numbers: pp.332-340

Abstract

Objectives Increases in ambient particulate matter (PM) have been associated with an elevated risk of stroke, myocardial ischaemia and coronary heart disease, with activation of blood coagulation likely playing an important role. PM-mediated activation of two major activation pathways of coagulation provides a potential mechanism for the observed association between PM and cardiovascular disease. However, it remains unclear which specific characteristics and components of air pollution are responsible.