Biological variations of ADAMTS13 and von Willebrand factor in human adults.

Kilercik M. , COŞKUN A. , SERTESER M. , İNAN D., Unsal I.

Biochemia medica, vol.24, no.1, pp.138-45, 2014 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 24 Issue: 1
  • Publication Date: 2014
  • Doi Number: 10.11613/bm.2014.015
  • Title of Journal : Biochemia medica
  • Page Numbers: pp.138-45


Background: The ultra-large von Willebrand factor (vWF) multimers are very active and must be degraded by ADAMTS13 for optimal activity. A severe functional deficiency of ADAMTS13 has been associated with thrombotic thrombocytopenic purpura. The correct interpretation of patient vWF and ADAMTS13 plasma levels requires an understanding of the biological variation associated with these analytes. In the present paper, we aimed to determine the biological variation of ADAMTS13 and vWF in human adults.