Thiamine: an efficient, biodegradable, green catalyst for one-pot synthesis of functionalized dihydropyridines
20th International Electronic Conference on Synthetic Organic Chemistry, ELECTR NETWORK, 1 - 30 Kasım 2016, (Tam Metin Bildiri)
- Yayın Türü: Bildiri / Tam Metin Bildiri
- Doi Numarası: 10.3390/ecsoc-20-a039
- Basıldığı Ülke: ELECTR NETWORK
- Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Hayır
Özet
An efficient protocol was developed for the four component and one-pot synthesis of functionalized 1, 4-dihydropyridines by thiamine (VB1) as biocatalyst via the reaction of malononitrile, substituted aldehydes, dimethylacetylenedicarboxylate and substituted aniline in ethanol at room temperature. Availability and non-toxicity are from important advantages of this green catalyst. Also, easy work-up, no chromatographic purifications and high yields in short reaction time are othere benefites of this procedure.