Hoyeraal-Hreidarsson Syndrome: An Extremely Rare Dyskeratosis Congenita Phenotype


Bakar O. , Isik U. , Canpolat C., ALANAY Y.

PEDIATRIC DERMATOLOGY, cilt.32, 2015 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 32 Konu: 6
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1111/pde.12693
  • Dergi Adı: PEDIATRIC DERMATOLOGY

Özet

Hoyeraal-Hreidarsson syndrome is a rare telomere biology disorder that is recognized as a severe variant of dyskeratosis congenita. We present a Libyan boy with hematologic and neurologic abnormalities with typical dermatologic manifestations of dyskeratosis congenita. Death usually occurs before the age of 4 years as a result of pancytopenia or malignant transformation of mucocutaneous lesions. The boy presented survived longer than 5 years. Early recognition and appropriate genetic counseling are crucial because of the high mortality of this genetic disorder.