JOURNAL OF NEUROSURGERY, vol.133, no.5, pp.1345-1354, 2020 (SCI-Expanded)
Article / Article
JOURNAL OF NEUROSURGERY
Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, EMBASE, MEDLINE
meningioma, precision medicine, genomics, clinical correlations, machine learning, oncology, MUTATIONS, AKT1, GRADE, SMO, EPENDYMOMAS, EXPRESSION, GERMLINE, TRAF7, KLF4
Acibadem Mehmet Ali Aydinlar University Affiliated:
OBJECTIVE Recent large-cohort sequencing studies have investigated the genomic landscape of meningiomas, identifying somatic coding alterations in NF2, SMARCB1, SMARCE1, TRAF7, KLF4, POLR2A, BAP1, and members of the PI3K and Hedgehog signaling pathways. Initial associations between clinical features and genomic subgroups have been described, including location, grade, and histology. However, further investigation using an expanded collection of samples is needed to confirm previous findings, as well as elucidate relationships not evident in smaller discovery cohorts.