Effect of oral tamoxifen on the healing of corrosive oesophageal burns in an experimental rat model

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Elmas O., Cevik M., Demir T., Ketani M. A.

INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY, cilt.19, sa.3, ss.351-356, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 19 Sayı: 3
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1093/icvts/ivu185
  • Dergi Adı: INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.351-356
  • Anahtar Kelimeler: Tamoxifen, Oesophageal burn, Alkali burn, Burn healing, TRIAL
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Hayır

Özet

OBJECTIVES: Corrosive oesophagitis is a common health problem in children. Scar tissue can develop during the recovery period, and as a result, serious narrowing of the oesophagus can develop, in turn causing morbidity and mortality. In previous studies, it was argued that tamoxifen (TAM) may have antifibrotic effects beyond its oestrogen antagonist or agonist properties. We aimed to examine the possible effects of TAM on fibrosis and stricture formation, which are complications of corrosive oesophagitis.