Effect of oral tamoxifen on the healing of corrosive oesophageal burns in an experimental rat model

Elmas, Onur; Cevik, MUAZEZ; Demir, Tuncer; Ketani, Muzaffer

doi:10.1093/icvts/ivu185

Effect of oral tamoxifen on the healing of corrosive oesophageal burns in an experimental rat model

Elmas O., Cevik M., Demir T., Ketani M. A.

INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY, cilt.19, sa.3, ss.351-356, 2014 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 19 Sayı: 3
Basım Tarihi: 2014
Doi Numarası: 10.1093/icvts/ivu185
Dergi Adı: INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.351-356
Anahtar Kelimeler: Tamoxifen, Oesophageal burn, Alkali burn, Burn healing, TRIAL
Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Hayır

Özet

OBJECTIVES: Corrosive oesophagitis is a common health problem in children. Scar tissue can develop during the recovery period, and as a result, serious narrowing of the oesophagus can develop, in turn causing morbidity and mortality. In previous studies, it was argued that tamoxifen (TAM) may have antifibrotic effects beyond its oestrogen antagonist or agonist properties. We aimed to examine the possible effects of TAM on fibrosis and stricture formation, which are complications of corrosive oesophagitis.