Effect of oral tamoxifen on the healing of corrosive oesophageal burns in an experimental rat model

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Elmas O., Cevik M., Demir T., Ketani M. A.

INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY, vol.19, no.3, pp.351-356, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 19 Issue: 3
  • Publication Date: 2014
  • Doi Number: 10.1093/icvts/ivu185
  • Journal Name: INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED)
  • Page Numbers: pp.351-356
  • Keywords: Tamoxifen, Oesophageal burn, Alkali burn, Burn healing, TRIAL
  • Acibadem Mehmet Ali Aydinlar University Affiliated: No

Abstract

OBJECTIVES: Corrosive oesophagitis is a common health problem in children. Scar tissue can develop during the recovery period, and as a result, serious narrowing of the oesophagus can develop, in turn causing morbidity and mortality. In previous studies, it was argued that tamoxifen (TAM) may have antifibrotic effects beyond its oestrogen antagonist or agonist properties. We aimed to examine the possible effects of TAM on fibrosis and stricture formation, which are complications of corrosive oesophagitis.