Acute isoniazid intoxication: case report

ALTUN D., ÇETİNGÖK H., Eren G. A., Cukurova Z., Hergunsel O.

MEDICAL JOURNAL OF BAKIRKOY, vol.11, no.1, pp.36-39, 2015 (ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 11 Issue: 1
  • Publication Date: 2015
  • Doi Number: 10.5350/btdmjb201511109
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.36-39
  • Keywords: Isoniasid intoxication, seizures, metabolic acidosis, METABOLIC-ACIDOSIS, STATUS EPILEPTICUS, PYRIDOXINE, SEIZURES, COMA
  • Acibadem Mehmet Ali Aydinlar University Affiliated: No


Isoniazid is a bactericidal antituberculosis drug, used commonly for treatment and prophylaxis of tuberculosis. Acute isoniazid intoxication is characterized by a clinical triad consisting of metabolic acidosis with a high anion gap resistant to treatment with sodium bicarbonate, seizures which may be fatal and refractory to standard anticonvulsant therapy, and coma. Pyridoxine, in a dose equivalent to the amount of isoniasid ingested, is the only effective antidote. Here, we reported a 14 years old female patient with the diagnosis of isoniasid intoxcication, successfully treated in our intensive care unit.