Associations of Meningioma Molecular Subgroup and Tumor Recurrence.


Youngblood M. W. , Miyagishima D. F. , Jin L., Gupte T., Li C., Duran D., ...More

Neuro-oncology, vol.23, pp.783-794, 2021 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 23
  • Publication Date: 2021
  • Doi Number: 10.1093/neuonc/noaa226
  • Title of Journal : Neuro-oncology
  • Page Numbers: pp.783-794
  • Keywords: meningioma genomics, molecular subgroups, precision medicine, tumor prognosis, TERT PROMOTER MUTATIONS, ALLELIC LOSS, AKT1, SMO, CLASSIFICATION, PROGRESSION, SYSTEM

Abstract

Background. We and others have identified mutually exclusive molecular subgroups of meningiomas; however, the implications of this classification for clinical prognostication remain unclear. Integrated genomic and epigenomic analyses implicate unique oncogenic processes associated with each subgroup, suggesting the potential for divergent clinical courses. The aim of this study was to understand the associated clinical outcomes of each subgroup, as this could optimize treatment for patients.