Is diabetes mellitus a risk factor for modic changes?: A novel model to understand the association between intervertebral disc degeneration and end-plate changes.

EKŞİ, Murat; KARA, MÜJDAT; Özcan-Ekşi, Emel; AYTAR, MURAT; GÜNGÖR, Abuzer; ÖZGEN, Serdar; PAMİR, Mustafa

doi:10.1016/j.jos.2019.09.005

Is diabetes mellitus a risk factor for modic changes?: A novel model to understand the association between intervertebral disc degeneration and end-plate changes.

EKŞİ M. Ş., KARA M., Özcan-Ekşi E. E., AYTAR M. H., GÜNGÖR A., ÖZGEN S., ...Daha Fazla

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 2019 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası:
Basım Tarihi: 2019
Doi Numarası: 10.1016/j.jos.2019.09.005
Dergi Adı: Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Evet

Özet

Objective: Mechanical failure and inflammatory response are two mechanisms proposed for the development of Modic changes, even though they have not been clearly demonstrated, yet. Diabetes mellitus (DM) harbors micro- and macroangiopathy due to the irreversible glycation of proteins, increased oxidative stress, and inflammation. In this study, we aimed to identify whether DM was associated with Modic changes in terms of inflammatory process.