Is diabetes mellitus a risk factor for modic changes?: A novel model to understand the association between intervertebral disc degeneration and end-plate changes.


EKŞİ M. Ş. , KARA M. , Özcan-Ekşi E. E. , AYTAR M. H. , GÜNGÖR A. , ÖZGEN S. , ...More

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 2019 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume:
  • Publication Date: 2019
  • Doi Number: 10.1016/j.jos.2019.09.005
  • Title of Journal : Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association

Abstract

Objective: Mechanical failure and inflammatory response are two mechanisms proposed for the development of Modic changes, even though they have not been clearly demonstrated, yet. Diabetes mellitus (DM) harbors micro- and macroangiopathy due to the irreversible glycation of proteins, increased oxidative stress, and inflammation. In this study, we aimed to identify whether DM was associated with Modic changes in terms of inflammatory process.