Porphyrin- or phthalocyanine-bridged silsesquioxane nanoparticles for two-photon photodynamic therapy or photoacoustic imaging

Mauriello-Jimenez, Chiara; Henry, Maxime; Aggad, Dina; Raehm, Laurence; Cattoen, Xavier; Man, Michel; Charnay, Clarence; Alpugan, Serkan; Ahsen, Vefa; Tarakci, Deniz; Maillard, Philippe; Maynadier, Marie; Garcia, Marcel; DUMOULIN , FABIENNE; Gary-Bobo, Magali; Coll, Jean-Luc; Josserand, Veronique; Durand, Jean-Olivier

doi:10.1039/c7nr04677d

Porphyrin- or phthalocyanine-bridged silsesquioxane nanoparticles for two-photon photodynamic therapy or photoacoustic imaging

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Mauriello-Jimenez C., Henry M., Aggad D., Raehm L., Cattoen X., Man M. W. C., ...More

NANOSCALE, vol.9, no.43, pp.16622-16626, 2017 (SCI-Expanded)

Publication Type: Article / Article
Volume: 9 Issue: 43
Publication Date: 2017
Doi Number: 10.1039/c7nr04677d
Journal Name: NANOSCALE
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED)
Page Numbers: pp.16622-16626
Acibadem Mehmet Ali Aydinlar University Affiliated: Yes

Abstract

Porphyrin- or phthalocyanine-bridged silsesquioxane nanoparticles (BSPOR and BSPHT) were prepared. Their endocytosis in MCF-7 cancer cells was shown with two-photon excited fluorescence (TPEF) imaging. With two-photon excited photodynamic therapy (TPE-PDT), BSPOR was more phototoxic than BSPHT, which in contrast displayed a very high signal for photoacoustic imaging in mice.