Porphyrin- or phthalocyanine-bridged silsesquioxane nanoparticles for two-photon photodynamic therapy or photoacoustic imaging


Mauriello-Jimenez C., Henry M., Aggad D., Raehm L., Cattoen X., Man M. W. C. , ...More

NANOSCALE, vol.9, no.43, pp.16622-16626, 2017 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 9 Issue: 43
  • Publication Date: 2017
  • Doi Number: 10.1039/c7nr04677d
  • Title of Journal : NANOSCALE
  • Page Numbers: pp.16622-16626

Abstract

Porphyrin- or phthalocyanine-bridged silsesquioxane nanoparticles (BSPOR and BSPHT) were prepared. Their endocytosis in MCF-7 cancer cells was shown with two-photon excited fluorescence (TPEF) imaging. With two-photon excited photodynamic therapy (TPE-PDT), BSPOR was more phototoxic than BSPHT, which in contrast displayed a very high signal for photoacoustic imaging in mice.