Porphyrin- or phthalocyanine-bridged silsesquioxane nanoparticles for two-photon photodynamic therapy or photoacoustic imaging

Mauriello-Jimenez, Chiara; Henry, Maxime; Aggad, Dina; Raehm, Laurence; Cattoen, Xavier; Man, Michel; Charnay, Clarence; Alpugan, Serkan; Ahsen, Vefa; Tarakci, Deniz; Maillard, Philippe; Maynadier, Marie; Garcia, Marcel; DUMOULIN , FABIENNE; Gary-Bobo, Magali; Coll, Jean-Luc; Josserand, Veronique; Durand, Jean-Olivier

doi:10.1039/c7nr04677d

Porphyrin- or phthalocyanine-bridged silsesquioxane nanoparticles for two-photon photodynamic therapy or photoacoustic imaging

Mauriello-Jimenez C., Henry M., Aggad D., Raehm L., Cattoen X., Man M. W. C., ...Daha Fazla

NANOSCALE, cilt.9, sa.43, ss.16622-16626, 2017 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 9 Sayı: 43
Basım Tarihi: 2017
Doi Numarası: 10.1039/c7nr04677d
Dergi Adı: NANOSCALE
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.16622-16626
Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Hayır

Özet

Porphyrin- or phthalocyanine-bridged silsesquioxane nanoparticles (BSPOR and BSPHT) were prepared. Their endocytosis in MCF-7 cancer cells was shown with two-photon excited fluorescence (TPEF) imaging. With two-photon excited photodynamic therapy (TPE-PDT), BSPOR was more phototoxic than BSPHT, which in contrast displayed a very high signal for photoacoustic imaging in mice.