Relationship of serum uric acid to measures of endothelial function and atherosclerosis in healthy adults


Erdogan D., Gullu H., Caliskan M., Yildirim E., Bilgi M., Ulus T., ...More

INTERNATIONAL JOURNAL OF CLINICAL PRACTICE, vol.59, no.11, pp.1276-1282, 2005 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 59 Issue: 11
  • Publication Date: 2005
  • Doi Number: 10.1111/j.1742-1241.2005.00621.x
  • Title of Journal : INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
  • Page Numbers: pp.1276-1282

Abstract

Although uric acid (UA) is considered as an antioxidant, the relationship between serum UA levels and cardiovascular diseases is not clear yet. Higher brachial artery resting diameter (BD), impaired brachial artery flow-mediated dilatation (FMD), increased carotid intima-media thickness (IMT), decreased aortic distensibility (AoD), and increased aortic stiffness index (AoSI) and elastic modulus (AoEM) are predictors for development and/or progression of atherosclerosis. In this study, BD, FMD, carotid IMT, AoD, AoSI and AoEM were studied in healthy subjects with UA concentrations in physiological range.