Anti-proliferative, apoptotic and signal transduction effects of hesperidin in non-small cell lung cancer cells

Cincin Z. B., Unlu M., Kiran B., Bireller E. S., Baran Y., ÇAKMAKOĞLU B.

CELLULAR ONCOLOGY, cilt.38, sa.3, ss.195-204, 2015 (SCI-Expanded) identifier identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 38 Sayı: 3
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1007/s13402-015-0222-z
  • Dergi Adı: CELLULAR ONCOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.195-204
  • Anahtar Kelimeler: Non-small cell lung cancer, Hesperidin, Anti-proliferative effect, Apoptosis, Gene expression profile, CITRUS FLAVONOIDS, COLON CARCINOGENESIS, KAPPA-B, GROWTH, INFLAMMATION, ANTICANCER, ACTIVATION, FLAVANONE, PATHWAYS, EFFICACY
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Hayır

Özet

Hesperidin, a glycoside flavonoid, is thought to act as an anti-cancer agent, since it has been found to exhibit both pro-apoptotic and anti-proliferative effects in several cancer cell types. The mechanisms underlying hesperidin-induced growth arrest and apoptosis are, however, not well understood. Here, we aimed to investigate the anti-proliferative and apoptotic effects of hesperidin on non-small cell lung cancer (NSCLC) cells and to investigate the mechanisms involved.