Akademik Veri Yönetim Sistemi
13th Annual NorPEN Meeting, Arhus, Danimarka, 11 - 12 Kasım 2021, ss.46
INTRODUCTION Paracetamol and ibuprofen are two of the most commonly prescribed analgesics to children in primary
care setting. Prescribing these drugs in doses higher than therapeutic levels might lead to increased risk of toxicity and
related adverse effects.
OBJECTIVES We aimed to evaluate whether paracetamol or ibuprofen containing pediatric prescriptions written in primary
care exceed the recommended maximum daily and one-time doses.
METHODS Paracetamol or ibuprofen containing prescriptions (PCP and ICP, respectively) written to children aged 1 to 11
by family physicians in Istanbul in 2016 were examined. Using average reference weight values in Turkish children, daily (60
mg/kg for paracetamol, 40 mg/kg for ibuprofen) and one-time (15 mg/kg for paracetamol, 10 mg/kg for ibuprofen)
maximum doses in each age and sex were determined. Percentage of prescriptions exceeding those limits and their
distribution by age and sex were evaluated.
RESULTS Based on the prescriptions, we identified 4.4% of PCPs
3.4±2.7
Daily dose lim were exceeded mostly in ages 1, 2,
and 4 in PCPs (9.2%, 7.0%, and 3.8%, respectively), and 1, 3, and 2 in ICPs (8.5%, 8.0%, and 7.0%, respectively). Frequency
s (5.1% vs. 3.7% in PCP, 3.3% - -16.5% of PCPs and 10.6%-13.2% of ICPs.
CONCLUSIONS Prescribing analgesics in supratherapeutic doses appears to be more frequent in girls and toddler age
group. Potential risk of toxicity should be kept in mind during determination of posology when prescribing analgesics to
children in primary care.