Microstructured Surfaces Cause Severe but Non-Detrimental Deformation of the Cell Nucleus
ADVANCED MATERIALS, cilt.21, sa.35, ss.3586-3591, 2009 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 21 Sayı: 35
- Basım Tarihi: 2009
- Doi Numarası: 10.1002/adma.200900582
- Dergi Adı: ADVANCED MATERIALS
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.3586-3591
- Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Hayır
Özet
Surface features on the length scale of organelles allow their manipulation. Here, we present observations of an unexpected deformation of nuclei within cells growing on surfaces with micrometer-sized pillars. Our results demonstrate that a microstructured surface can induce strong shape deformations in cells, without harmful consequences, and strongly suggest that these are limited to cancerous cells.