Hippocampal Neuronal Damage in Rats Exposed to a Double Hit: Irradiation and Hyperthermia

ERKANLI ŞENTÜRK G., İŞLER C., KEMERDERE R., ULU M. O., Umay C., Ozkaymakci A., ...More

TURKISH NEUROSURGERY, vol.21, no.4, pp.454-460, 2011 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 21 Issue: 4
  • Publication Date: 2011
  • Doi Number: 10.5137/1019-5149.jtn.4012-10.1
  • Journal Name: TURKISH NEUROSURGERY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.454-460
  • Keywords: Hippocampus, Hyperthermia, Irradiation, Neuronal damage, Rat, FACTOR IMMUNOREACTIVE CELLS, TIME-DEPENDENT CHANGES, FEBRILE SEIZURES, CORTICAL DYSPLASIA, MIGRATION, EPILEPSY, MODEL, DISORDERS, CORTEX
  • Acibadem Mehmet Ali Aydinlar University Affiliated: No

Abstract

AIM: In utero irradiation models induce diffuse neuronal damage. Experimental studies have shown that hyperthermia induced seizures are easily elicited and have high mortality accompanied by neuronal loss. Neuronal damage and loss are the results of cell death coupled with cortical development in altered cellular development. The aim of the study was to investigate the changes in hippocampus that was exposed to irradiation and hyperthermia.