Hippocampal Neuronal Damage in Rats Exposed to a Double Hit: Irradiation and Hyperthermia

Senturk G. E. , Isler C., Kemerdere R., Ulu M. O. , Umay C., Ozkaymakci A., ...More

TURKISH NEUROSURGERY, vol.21, no.4, pp.454-460, 2011 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 21 Issue: 4
  • Publication Date: 2011
  • Doi Number: 10.5137/1019-5149.jtn.4012-10.1
  • Title of Journal : TURKISH NEUROSURGERY
  • Page Numbers: pp.454-460


AIM: In utero irradiation models induce diffuse neuronal damage. Experimental studies have shown that hyperthermia induced seizures are easily elicited and have high mortality accompanied by neuronal loss. Neuronal damage and loss are the results of cell death coupled with cortical development in altered cellular development. The aim of the study was to investigate the changes in hippocampus that was exposed to irradiation and hyperthermia.