alpha-Melanocyte stimulating hormone has beneficial effects on cerulein-induced acute pancreatitis

Jahovic N., Arbak S., Tekeli O., Alican I.

PEPTIDES, cilt.25, sa.1, ss.129-132, 2004 (SCI-Expanded) identifier identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 25 Sayı: 1
  • Basım Tarihi: 2004
  • Doi Numarası: 10.1016/j.peptides.2003.11.008
  • Dergi Adı: PEPTIDES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.129-132
  • Anahtar Kelimeler: pancreatitis, alpha-melanocyte stimulating hormone, neutrophils, rat, NF-KAPPA-B, INFLAMMATION, MSH, MODULATION, ADHESION, INJURY, RAT
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Hayır

Özet

We investigated the effect of alpha-melanocyte stimulating hormone (alpha-MSH) on cerulein induced acute pancreatitis in rats. alpha-MSH treatment (50 mug per rat, intraperitoneally) prior to cerulein reduced the plasma amylase level, pancreatic weight, pancreatic myeloperoxidase activity and the severity of the lesions microscopically. These data suggest that a-MSH has a protective effect on cerulein-induced acute pancreatitis and this effect could be attributed, at least in part, to decreased tissue leukocyte infiltration and thus, to decreased pro-inflammatory cytokine production and/or oxygen- and nitrogen-derived reactive metabolite release. (C) 2004 Elsevier Inc. All nights reserved.