IGFBP-4: A promising biomarker for lung cancer.


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Nur S. I. , Ozturk A., Kavas M., Bulut I., Alparslan S., Aydogan E. S. , ...More

Journal of medical biochemistry, vol.40, pp.237-244, 2021 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 40
  • Publication Date: 2021
  • Doi Number: 10.5937/jomb0-25629
  • Title of Journal : Journal of medical biochemistry
  • Page Numbers: pp.237-244
  • Keywords: lung cancer, biomarkers, IGFBP-4, PAPP-A, IGF-1, PLASMA PROTEIN-A, BINDING PROTEIN-4, PAPP-A, SERUM, EXPRESSION, PROGNOSIS, DIAGNOSIS, CELLS, FLUID, AXIS

Abstract

Background: Insulin-like growth factor binding protein-4 (IGFBP-4), a member of the insulin-like growth factor (IGF) family, transports, and regulates the activity of IGFs. The pregnancy-associated plasma protein-A (PAPP-A) has proteolytic activity towards IGFBP-4, and both proteins have been associated with a variety of cancers, including lung cancer. Thus, we aimed to evaluate the use of IGFBP-4 and PAPP-A as potential biomarkers for lung cancer.