Journal of medical biochemistry, vol.40, pp.237-244, 2021 (SCI-Expanded)
Article / Article
Journal of medical biochemistry
Science Citation Index Expanded (SCI-EXPANDED)
lung cancer, biomarkers, IGFBP-4, PAPP-A, IGF-1, PLASMA PROTEIN-A, BINDING PROTEIN-4, PAPP-A, SERUM, EXPRESSION, PROGNOSIS, DIAGNOSIS, CELLS, FLUID, AXIS
Acibadem Mehmet Ali Aydinlar University Affiliated:
Background: Insulin-like growth factor binding protein-4 (IGFBP-4), a member of the insulin-like growth factor (IGF) family, transports, and regulates the activity of IGFs. The pregnancy-associated plasma protein-A (PAPP-A) has proteolytic activity towards IGFBP-4, and both proteins have been associated with a variety of cancers, including lung cancer. Thus, we aimed to evaluate the use of IGFBP-4 and PAPP-A as potential biomarkers for lung cancer.