IGFBP-4: A promising biomarker for lung cancer.

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Nur S. I., Ozturk A., Kavas M., Bulut I., Alparslan S., Aydogan E. S., ...Daha Fazla

Journal of medical biochemistry, cilt.40, ss.237-244, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 40
  • Basım Tarihi: 2021
  • Doi Numarası: 10.5937/jomb0-25629
  • Dergi Adı: Journal of medical biochemistry
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, Central & Eastern European Academic Source (CEEAS), EMBASE, Veterinary Science Database, Directory of Open Access Journals
  • Sayfa Sayıları: ss.237-244
  • Anahtar Kelimeler: lung cancer, biomarkers, IGFBP-4, PAPP-A, IGF-1, PLASMA PROTEIN-A, BINDING PROTEIN-4, PAPP-A, SERUM, EXPRESSION, PROGNOSIS, DIAGNOSIS, CELLS, FLUID, AXIS
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Evet

Özet

Background: Insulin-like growth factor binding protein-4 (IGFBP-4), a member of the insulin-like growth factor (IGF) family, transports, and regulates the activity of IGFs. The pregnancy-associated plasma protein-A (PAPP-A) has proteolytic activity towards IGFBP-4, and both proteins have been associated with a variety of cancers, including lung cancer. Thus, we aimed to evaluate the use of IGFBP-4 and PAPP-A as potential biomarkers for lung cancer.