Effect of pregabalin on post-dural-puncture headache following spinal anesthesia and lumbar puncture

Huseyinoglu U., Huseyinoglu N., Hamurtekin E., Aygun H., Sulu B.

JOURNAL OF CLINICAL NEUROSCIENCE, vol.18, no.10, pp.1365-1368, 2011 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 18 Issue: 10
  • Publication Date: 2011
  • Doi Number: 10.1016/j.jocn.2011.02.029
  • Journal Name: JOURNAL OF CLINICAL NEUROSCIENCE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1365-1368
  • Keywords: Headache, Lumbar puncture, Pregabalin, Spinal anesthesia, DEPENDENT CALCIUM-CHANNELS, NEUROPATHIC PAIN, DOUBLE-BLIND, SUBUNIT, MECHANISMS, STREPTOZOCIN, GABAPENTIN, ALLODYNIA, MIGRAINE, TARGET
  • Acibadem Mehmet Ali Aydinlar University Affiliated: No

Abstract

In this study, we aimed to investigate the effect of pregabalin on post-dural-puncture headache (PDPH). Forty patients who developed PDPH after spinal anesthesia or diagnostic and/or therapeutic lumbar puncture were divided into two groups and followed for 5 days. The first group received 150 mg/day oral pregabalin for the first 3 days, then 300 mg/day for a further 2 days. The second group received a placebo for the same length of time. Patient headaches were scored using the visual analog scale, and diclofenac sodium and pethidine requirements were recorded. Relative to the placebo group, the group administered pregabalin had significantly lower visual analog scale scores after the second day of treatment, and had significantly lower diclofenac sodium requirements. Our results indicate that pregabalin may be useful for the management of PDPH. (C) 2011 Elsevier Ltd. All rights reserved.