GnRH agonist leuprolide acetate does not confer any protection against ovarian damage induced by chemotherapy and radiation in vitro


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Bildik G., Akin N., Senbabaoglu F., Sahin G. N. , Karahuseyinoglu S., Ince Ü., ...More

HUMAN REPRODUCTION, vol.30, no.12, pp.2912-2925, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 30 Issue: 12
  • Publication Date: 2015
  • Doi Number: 10.1093/humrep/dev257
  • Journal Name: HUMAN REPRODUCTION
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED)
  • Page Numbers: pp.2912-2925
  • Keywords: chemotherapy, ovarian failure, GnRH agonist, apoptosis, follicle reserve, granulosa cells, steroidogenic activity, BREAST-CANCER CHEMOTHERAPY, FERTILITY PRESERVATION, PREMENOPAUSAL WOMEN, ADJUVANT TREATMENT, HORMONE AGONISTS, GROWTH, CYCLOPHOSPHAMIDE, TRIPTORELIN, PACLITAXEL, DOCETAXEL
  • Acibadem Mehmet Ali Aydinlar University Affiliated: Yes

Abstract

STUDY QUESTION: Is there any in vitro evidence for or against ovarian protection by co-administration of a GnRH agonist with chemotherapy in human?