Aromatase inhibitors decrease radiation-induced lung fibrosis: Results of an experimental study

Altinok A. Y. , Yildirim S., Altug T., Sut N., Ober A., Ozsahin E. M. , ...More

BREAST, vol.28, pp.174-177, 2016 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 28
  • Publication Date: 2016
  • Doi Number: 10.1016/j.breast.2016.04.003
  • Title of Journal : BREAST
  • Page Numbers: pp.174-177


Purpose: In experimental and clinical trials, tamoxifen (TAM) has been shown to increase radiation-induced lung fibrosis (RILF). Furthermore, aromatase inhibitors (AI) have been shown to be superior to TAM in the adjuvant setting and preclinical data suggest that letrozole (LET) sensitizes breast cancer cells to ionizing radiation in other studies. In this experimental study, we evaluated whether AI have any impact on the development of RILF in rats.