Schiff Base-Poloxamer P85 Combination Prevents Prostate Cancer Progression in C57/Bl6 Mice

Dogan A., Demirci S., Turkmen N. B., Caglayan A. B., Aydin S., Telci D., ...More

PROSTATE, vol.76, no.15, pp.1454-1463, 2016 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 76 Issue: 15
  • Publication Date: 2016
  • Doi Number: 10.1002/pros.23229
  • Journal Name: PROSTATE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1454-1463
  • Keywords: Schiff base, pluronic, P85, prostate cancer, tramp-C1, COPPER(II) COMPLEXES, PLURONIC P85, CHEMOTHERAPY, ESTRAMUSTINE, TOXICITY, REVEALS, GRADE
  • Acibadem Mehmet Ali Aydinlar University Affiliated: No

Abstract

BACKGROUNDProstate cancer which is the second most common cause of death among men has a high incidence in recent years. Current therapeutic regimens should be improved to overcome drug resistance. At the metastatic stage, tumors become refractory to established chemotherapeutic treatments and cause serious problems at the clinics. Development of new drug molecules that are able to transport through the membrane easily and kill tumor cells rapidly is of great interest.