What Is the Optimal Treatment of Large Brain Metastases? An Argument for a Multidisciplinary Approach

Choi C. Y. H., Chang S. D., Gibbs I. C., Adler J. R., Harsh G. R., Atalar B., ...More

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, vol.84, no.3, pp.688-693, 2012 (SCI-Expanded) identifier identifier identifier


Purpose: Single-modality treatment of large brain metastases (>2 cm) with whole-brain irradiation, stereotactic radiosurgery (SRS) alone, or surgery alone is not effective, with local failure (LF) rates of 50% to 90%. Our goal was to improve local control (LC) by using multimodality therapy of surgery and adjuvant SRS targeting the resection cavity.