What Is the Optimal Treatment of Large Brain Metastases? An Argument for a Multidisciplinary Approach

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Choi C. Y. H., Chang S. D., Gibbs I. C., Adler J. R., Harsh G. R., Atalar B., ...More

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, vol.84, no.3, pp.688-693, 2012 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 84 Issue: 3
• Publication Date: 2012
• Doi Number: 10.1016/j.ijrobp.2012.01.028
• Journal Name: INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.688-693
• Acibadem Mehmet Ali Aydinlar University Affiliated: Yes

Abstract

Purpose: Single-modality treatment of large brain metastases (>2 cm) with whole-brain irradiation, stereotactic radiosurgery (SRS) alone, or surgery alone is not effective, with local failure (LF) rates of 50% to 90%. Our goal was to improve local control (LC) by using multimodality therapy of surgery and adjuvant SRS targeting the resection cavity.