What Is the Optimal Treatment of Large Brain Metastases? An Argument for a Multidisciplinary Approach


Choi C. Y. H. , Chang S. D. , Gibbs I. C. , Adler J. R. , Harsh G. R. , Atalar B. , ...More

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, vol.84, no.3, pp.688-693, 2012 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 84 Issue: 3
  • Publication Date: 2012
  • Doi Number: 10.1016/j.ijrobp.2012.01.028
  • Title of Journal : INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
  • Page Numbers: pp.688-693

Abstract

Purpose: Single-modality treatment of large brain metastases (>2 cm) with whole-brain irradiation, stereotactic radiosurgery (SRS) alone, or surgery alone is not effective, with local failure (LF) rates of 50% to 90%. Our goal was to improve local control (LC) by using multimodality therapy of surgery and adjuvant SRS targeting the resection cavity.