A contemporary framework of language processing in the human brain in the context of preoperative and intraoperative language mapping

Middlebrooks E. H. , Yagmurlu K., Szaflarski J. P. , Rahman M., Bozkurt B.

NEURORADIOLOGY, vol.59, no.1, pp.69-87, 2017 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 59 Issue: 1
  • Publication Date: 2017
  • Doi Number: 10.1007/s00234-016-1772-0
  • Title of Journal : NEURORADIOLOGY
  • Page Numbers: pp.69-87


The emergence of advanced in vivo neuroimaging methods has redefined the understanding of brain function with a shift from traditional localizationist models to more complex and widely distributed neural networks. In human language processing, the traditional localizationist models of Wernicke and Broca have fallen out of favor for a dual-stream processing system involving complex networks organized over vast areas of the dominant hemisphere. The current review explores the cortical function and white matter connections of human language processing, as well as their relevance to surgical planning.