Investigation of Schwann Cells at Neoplastic Cell Sites Before the Onset of Cancer Invasion

Creative Commons License

Demir I. E. , Boldis A., Pfitzinger P. L. , Teller S., Brunner E., Klose N., ...More

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, vol.106, no.8, 2014 (SCI-Expanded) identifier identifier identifier


Background In neural invasion (NI), cancer cells are classically assumed to actively invade nerves and to cause local recurrence and pain. However, the opposite possibility, that nerves may reach cancer cells even in their preinvasive stage and thereby promote cancer spread, has not yet been genuinely considered. The present study analyzes the reaction of Schwann cells of peripheral nerves to carcinogenesis in pancreatic cancer and colon cancer.