Wilms Tumor, AML and Medulloblastoma in a Child With Cancer Prone Syndrome of Total Premature Chromatid Separation and Fanconi Anemia

Sari N., AKYÜZ C., Aktas D., GÜMRÜK F., ORHAN D., ALİKAŞİFOĞLU M., ...Daha Fazla

PEDIATRIC BLOOD & CANCER, cilt.53, sa.2, ss.208-210, 2009 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 53 Sayı: 2
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1002/pbc.21966
  • Dergi Adı: PEDIATRIC BLOOD & CANCER
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.208-210
  • Anahtar Kelimeler: AML, Fanconi anemia, medulloblastoma, total premature chromatid separation, Wilms tumor, MOSAIC VARIEGATED ANEUPLOIDY, CENTROMERE DIVISION PCD, CHROMOSOMAL INSTABILITY, ASSOCIATION, MUTATIONS
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Hayır

Özet

Wilms tumor (WT) is the most common primary renal tumor in childhood. The Occurrence of WT in patients with growth retardation, mental retardation and central nervous system abnormalities in association with premature chromatid separation (PCS) and mosaic variegated aneuploidy has been previously described in only 10 patients. Here we report the very rare occurrence of WT with two other malignancies, acute myeloid leukemia and medulloblastoma in association with chromosomal instability. This is a novel presentation of Fanconi anemia with this cytogenetic abnormality. Pediatr Blood Cancer 2009;53:208-210. (C) 2009 Wiley-Liss, Inc.