Prognostic importance of survivin, Ki-67, and topoisomerase II alpha in ovarian carcinoma


Gulec U. K. , GÜMÜRDÜLÜ D., GÜZEL A. B. , PAYDAŞ S., SEYDAOĞLU G., AÇIKALIN A., ...More

ARCHIVES OF GYNECOLOGY AND OBSTETRICS, vol.289, no.2, pp.393-398, 2014 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 289 Issue: 2
  • Publication Date: 2014
  • Doi Number: 10.1007/s00404-013-3000-z
  • Title of Journal : ARCHIVES OF GYNECOLOGY AND OBSTETRICS
  • Page Numbers: pp.393-398
  • Keywords: Epithelial ovarian cancer, Ki-67, Prognosis, Platinum resistance, Survivin, Topoisomerase II alpha, EXPRESSION, CANCER, APOPTOSIS, GENE, CHEMOTHERAPY, NUCLEAR, CELLS

Abstract

Stage, tumor grade and histological subtype determine the clinical behavior in ovarian tumors. Some additional factors are related to tumor cell biology and are the useful predictors for identifying the patients with poor prognosis. The aim of this study is to evaluate the prognostic significance of survivin, Ki-67 and Topoisomerase II alpha (TOPO II alpha) in epithelial ovarian cancer (EOC).