Serum sclerostin levels, arteriovenous fistula calcification and 2-years all-cause mortality in prevalent hemodialysis patients


Kirkpantur A., Balci M., Turkvatan A., Afsar B.

NEFROLOGIA, cilt.36, ss.24-32, 2016 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 36 Konu: 1
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1016/j.nefro.2015.07.006
  • Dergi Adı: NEFROLOGIA
  • Sayfa Sayıları: ss.24-32

Özet

Background: Bone and mineral abnormalities, and cardiovascular calcification are associated with increased cardiovascular mortality in patients with chronic kidney disease (CKD). Recent studies have implicated Wnt signaling pathway in the pathogenesis of bone metabolism and vascular calcification. Sclerostin is a soluble inhibitor of Wnt signaling pathway and has been shown to be associated with decreased bone tumover and vascular calcification in CKD patients.