Association of Pro-apoptotic Bad Gene Expression Changes with Benign Thyroid Nodules


Gul N., Temel B., Ustek D., Sirma-Ekmekci S., Kapran Y., Tunca F., ...Daha Fazla

IN VIVO, cilt.32, ss.555-559, 2018 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 32 Konu: 3
  • Basım Tarihi: 2018
  • Doi Numarası: 10.21873/invivo.11275
  • Dergi Adı: IN VIVO
  • Sayfa Sayıları: ss.555-559

Özet

Background/Aim: This study aimed to investigate the role of the mitochondrial apoptotic pathway in benign thyroid nodules. Materials and Methods: Paired samples of nodular and normal tissues were collected from 26 patients with nodular goiters undergoing thyroidectomy. Variable expression of Bcl-2, Bax and Bad genes were evaluated by quantitative PCR. Results: Expression level of Bad gene in nodules was found to be significantly decreased compared to normal tissues p=0.049). A positive correlation was observed between nodule size and Bad expression levels (correlation coefficient=0.563, p=0.004); and this correlation was stronger in hot nodules (n=18, correlation coefficient=0.689, p=0.003). No significant difference was observed between nodular and normal tissue expressions of Bax and Bcl-2. Conclusion: These results suggest that Bad expression correlates with the size of benign thyroid nodules and also its relatively lower expression in nodules, warrant further investigation.