Association of Pro-apoptotic Bad Gene Expression Changes with Benign Thyroid Nodules

Gul N., Temel B., Ustek D., Sirma-Ekmekci S., Kapran Y., Tunca F., ...More

IN VIVO, vol.32, no.3, pp.555-559, 2018 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 32 Issue: 3
  • Publication Date: 2018
  • Doi Number: 10.21873/invivo.11275
  • Title of Journal : IN VIVO
  • Page Numbers: pp.555-559


Background/Aim: This study aimed to investigate the role of the mitochondrial apoptotic pathway in benign thyroid nodules. Materials and Methods: Paired samples of nodular and normal tissues were collected from 26 patients with nodular goiters undergoing thyroidectomy. Variable expression of Bcl-2, Bax and Bad genes were evaluated by quantitative PCR. Results: Expression level of Bad gene in nodules was found to be significantly decreased compared to normal tissues p=0.049). A positive correlation was observed between nodule size and Bad expression levels (correlation coefficient=0.563, p=0.004); and this correlation was stronger in hot nodules (n=18, correlation coefficient=0.689, p=0.003). No significant difference was observed between nodular and normal tissue expressions of Bax and Bcl-2. Conclusion: These results suggest that Bad expression correlates with the size of benign thyroid nodules and also its relatively lower expression in nodules, warrant further investigation.