Factor V Leiden Mutation-Related Chronic Skin Ulcers
INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS, cilt.12, sa.1, ss.35-38, 2013 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 12 Sayı: 1
- Basım Tarihi: 2013
- Doi Numarası: 10.1177/1534734613479379
- Dergi Adı: INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.35-38
- Anahtar Kelimeler: factor V Leiden mutation, chronic skin ulcer, anticoagulant treatment, ACTIVATED PROTEIN-C, RESISTANCE
- Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Hayır
Özet
Chronic skin ulcers require extensive, systemic differential diagnosis; thus, they are difficult to diagnose and treat. Transient or persistent hypercoagulable states are among the rare causes of skin ulcers. Here, we present the case of a 27-year-old woman patient with recurrent, nonhealing skin ulcers of 8 years' duration, who had been treated unsuccessfully with various medications under different diagnoses at different clinics. On admission, a skin biopsy demonstrated occlusive vasculopathy, and the search for an inherited hypercoagulable state revealed a heterozygous factor V Leiden mutation. The patient was treated with anticoagulants and hyperbaric oxygen. On treatment, the skin lesions healed and did not recur.