Systematic review of the biological variation data for diabetes related analytes

Gonzalez-Lao E., Corte Z., Simon M., Ricos C., Coskun A. , Braga F., ...More

CLINICA CHIMICA ACTA, vol.488, pp.61-67, 2019 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 488
  • Publication Date: 2019
  • Doi Number: 10.1016/j.cca.2018.10.031
  • Title of Journal : CLINICA CHIMICA ACTA
  • Page Numbers: pp.61-67
  • Keywords: Biological variation, Analytical performance specifications, Diabetes mellitus, Glucose, Glycated haemoglobin, CLINICAL-CHEMISTRY, EUROPEAN FEDERATION, CRITICAL-APPRAISAL, COLLATED DATA, VARIABILITY, ASSOCIATION, CHECKLIST, UPDATE


Background: Objective interpretation of laboratory test results used to diagnose and monitor diabetes mellitus in part requires the application of biological variation data (BVD). The quality of published BVD has been questioned. The aim of this study was to quality assess publications reporting BVD for diabetes-related analytes using the Biological Variation Data Critical Appraisal Checklist (BIVAC); to assess whether published BVD are fit for purpose and whether the study design and population attributes influence BVD estimates and to undertake a meta-analysis of the BVD from BIVAC-assessed publications.