Whole exome sequencing-based analysis to identify DNA damage repair deficiency as a major contributor to gliomagenesis in adult diffuse gliomas

Ülgen, E; Can, ÖZGE; Bilguvar, K; Oktay, Y; Akyerli, Cemaliye; Danyeli, Ayça; Yakıcıer, MUSTAFA; Sezerman, Osman; Pamir, MUSTAFA; Özduman, Koray

doi:10.3171/2019.1.jns182938

Whole exome sequencing-based analysis to identify DNA damage repair deficiency as a major contributor to gliomagenesis in adult diffuse gliomas

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Ülgen E., Can Ö. , Bilguvar K., Oktay Y., Akyerli C. , Danyeli A. , ...More

JOURNAL OF NEUROSURGERY, vol.132, no.5, pp.1435-1446, 2020 (Journal Indexed in SCI)

Publication Type: Article / Article
Volume: 132 Issue: 5
Publication Date: 2020
Doi Number: 10.3171/2019.1.jns182938
Title of Journal : JOURNAL OF NEUROSURGERY
Page Numbers: pp.1435-1446

Abstract

OBJECTIVE Processes that cause or contribute to cancer, such as aging, exposure to carcinogens, or DNA damage repair deficiency (DDRd), create predictable and traceable nucleotide alterations in one's genetic code (termed "mutational signatures"). Large studies have previously identified various such mutational signatures across cancers that can be attributed to the specific causative processes. To gain further insight into the processes in glioma development, the authors analyzed mutational signatures in adult diffuse gliomas (DGs).