Whole exome sequencing-based analysis to identify DNA damage repair deficiency as a major contributor to gliomagenesis in adult diffuse gliomas

Ülgen E., Can Ö. , Bilguvar K., Oktay Y., Akyerli C. , Danyeli A. , ...More

JOURNAL OF NEUROSURGERY, vol.132, no.5, pp.1435-1446, 2020 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 132 Issue: 5
  • Publication Date: 2020
  • Doi Number: 10.3171/2019.1.jns182938
  • Title of Journal : JOURNAL OF NEUROSURGERY
  • Page Numbers: pp.1435-1446


OBJECTIVE Processes that cause or contribute to cancer, such as aging, exposure to carcinogens, or DNA damage repair deficiency (DDRd), create predictable and traceable nucleotide alterations in one's genetic code (termed "mutational signatures"). Large studies have previously identified various such mutational signatures across cancers that can be attributed to the specific causative processes. To gain further insight into the processes in glioma development, the authors analyzed mutational signatures in adult diffuse gliomas (DGs).