Calcium Imaging of Nerve-Mast Cell Signaling in the Human Intestine.


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Buhner S., Barki N., Greiter W., Giesbertz P., Demir I., Ceyhan G., ...More

Frontiers in physiology, vol.8, pp.971, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 8
  • Publication Date: 2017
  • Doi Number: 10.3389/fphys.2017.00971
  • Journal Name: Frontiers in physiology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED)
  • Page Numbers: pp.971
  • Keywords: enteric nervous system, neuropeptides, Ca2+ imaging, neuro-immune, CGRP, SP, VIP, human gut, IRRITABLE-BOWEL-SYNDROME, HUMAN SUBMUCOUS PLEXUS, IN-VITRO, SUBSTANCE-P, GUINEA-PIG, MEDIATOR RELEASE, IMMUNOGLOBULIN-E, ENTERIC NEURONS, EXCITES NEURONS, HUMAN GUT
  • Acibadem Mehmet Ali Aydinlar University Affiliated: No

Abstract

Introduction: It is suggested that an altered microenvironment in the gut wall alters communication along amast cell nerve axis. We aimed to record for the first time signaling between mast cells and neurons in intact human submucous preparations.