A comparison of the effects of 50% oxygen combined with CPAP to the non-ventilated lung vs. 100% oxygen on oxygenation during one-lung ventilation

Sentürk M., Layer M., Pembeci K., Toker A., Akpir K., Wiedemann K.

ANASTHESIOLOGIE INTENSIVMEDIZIN NOTFALLMEDIZIN SCHMERZTHERAPIE, cilt.39, sa.6, ss.360-364, 2004 (SCI-Expanded, Scopus)

Özet

Objective: In a prospective, randomised, double-blind study the effects of FiO(2) of 0,5 with CPAP and a FiO(2) of 1.0 without CPAP on oxygenation and pulmonary shunt during one-lung ventilation (OLV) were examined. Methods: In 20 patients undergoing thoracotomy (ASA II/III) two sequential ventilation methods were used during OLV: a) FiO(2) Of 1.0 (OLV-100) and b) a FiO(2) of 0.5 in N2O combined with CPAP of 5 cm H2O to the non-ventilated lung (OLV-CPAP), whereby the sequence in 10 patients was OLV-CPAP followed by OLV-100; and the opposite in the remaining 10 patients. Operating conditions were graded by the surgeon. Results: OLV-CPAP was associated with a better oxygenation and a lower shunt compared to OLV-100 (paO(2):198 +/- 40 mmHg vs 181 +/- 38 mmHg; p < 0.05 and Qs/Qt: 30 +/- 6% vs. 34 +/- 8%; p < 0.01, respectively). The different sequence of the ventilation methods did not cause significant differences in the results. The surgical conditions were not impaired by the CPAP of 5 cm H2O. Conclusion: The application of low FiO(2) with CPAP provided a better oxygenation and a lower pulmonary shunt during the OLV compared to high FiO(2) without CPAP.