Evaluation Of Bone Disease In Kidney Transplant Patients


Alış G., Alış M., Ertürk T. , Karayağız A. H. , Berber İ. , Çakır Ü.

Türkiye Organ Nakli Kuruluşları Koordinasyon Derneği XI. Kongresi, Transplantasyon'16, Konya, Türkiye, 13 - 15 Ekim 2016, ss.81

  • Basıldığı Şehir: Konya
  • Basıldığı Ülke: Türkiye
  • Sayfa Sayıları: ss.81

Özet

Aim : Kidney transplant patients are known to have bone disease, specifically osteoporosis. In this descriptive clinical study we aimed to evaluate the incidence of osteoporosis and determine the risk factors among our transplant patients.


Methods : A total of 109 patients (82 male, 27 female) aged 19 to 70 years who had undergone kidney transplantation 12 to 69 months previously, were included in the study. Bone mineral densitometry was performed using dual-energy x-ray absorptiometry. The correlation between femur and lumbar spine T scores with age, gender, posttransplantation duration, serum 25 hydroxy vitamin D, serum parathyroid hormone (iPTH), Calcium (Ca), Phosphorus (P), serum creatinine (Cr), and Hemoglobin (Hb) values were investigated.


Results : The incidence of osteoporosis was 22% (24 of 109 patients). The most common sites of osteoporosis were the femur (osteoporotic in 17 patients [15.5%] and osteopenic in 57 [52.2%]) and the lumbar spine (osteoporotic in 24 patients [22%] and osteopenic in 50 [45.8%]). Osteoporosis was found to have no relationship with and age and gender. There was a significant negative correlation between both femur and lumbar spine T scores with serum iPTH (p=0,013 and 0,033 respectively). However only femur T scores were negatively correlated with serum P (p=0,037).


Conclusion : Bone disease after transplantation is a frequent complication which may decrease the quality of life, so we believe to reduce the morbidity; it is required to detect and correct the risk factors of this complex pathophysiological situation.