No Association between Polymorphisms of Vitamin D and Oxytocin Receptor Genes and Autistic Spectrum Disorder in a Sample of Turkish Children


Bozdogan S. T. , Kutuk M. O. , Tufan E. , Altintas Z., Temel G. O. , Toros F.

CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE, cilt.16, ss.415-421, 2018 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 16 Konu: 4
  • Basım Tarihi: 2018
  • Doi Numarası: 10.9758/cpn.2018.16.4.415
  • Dergi Adı: CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE
  • Sayfa Sayıları: ss.415-421

Özet

Objective: Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impairment in social skills and communication with repetitive behaviors. Etiology is still unclear although it is thought to develop with interaction of genes and environmental factors. Oxytocin has extensive effects on intrauterine brain development. Vitamin D, affects neural development and differentiation and contributes to the regulation of around 900 genes including oxytocin receptor gene. In the present study, the contribution of D vitamin receptor and oxytocin receptor gene polymorphisms in the development of ASD in Turkish community was investigated. To our knowledge, this is the first study examining these two associated genes together in the literature.