CELLULAR ONCOLOGY, vol.40, no.6, pp.563-578, 2017 (SCI-Expanded)
Article / Article
Science Citation Index Expanded (SCI-EXPANDED)
AKR1B1, AKR1B10, Colorectal cancer, Inflammation, Motility, Prognosis, NF-KAPPA-B, BREAST-CANCER, CELL-PROLIFERATION, INHIBITION, EXPRESSION, GROWTH, IDENTIFICATION, INFLAMMATION, METASTASIS, TRANSITION
Acibadem Mehmet Ali Aydinlar University Affiliated:
Aldo-keto reductases (including AKR1B1 and AKR1B10) constitute a family of oxidoreductases that have been implicated in the pathophysiology of diabetes and cancer, including colorectal cancer (CRC). Available data indicate that, despite their similarities in structure and enzymatic functions, their roles in CRC may be divergent. Here, we aimed to determine the expression and functional implications of AKR1B1 and AKR1B10 in CRC.