Co-transplantation of mesenchymal stromal cell and haploidentical hematopoietic stem cell with TCR alpha beta depletion in children with primary immunodeficiency syndromes


ATAY D. , AKÇAY A. , Akinci B. , DEMİR YENİGÜRBÜZ F. , Ovali E., Ozturk G.

PEDIATRIC TRANSPLANTATION, 2021 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume:
  • Publication Date: 2021
  • Doi Number: 10.1111/petr.14120
  • Title of Journal : PEDIATRIC TRANSPLANTATION
  • Keywords: haploidentical HSCT, MSC, primary immunodeficiency syndromes, TCR alpha beta depletion, VERSUS-HOST-DISEASE, STEROID-RESISTANT, PERIPHERAL-BLOOD, ADENOVIRUS, COTRANSPLANTATION, RECOVERY, THERAPY, DONORS

Abstract

Background: Haploidentical HSCT is a good option for children with PIDs lacking an HLA-matched donor. Co-transplantation of MSCs during haploidentical HSCT in patients with PIDs may enhance engraftment, decrease the risk of GVHD, and ensure stable donor chimerism.