Akademik Veri Yönetim Sistemi
San Antonio Breast Cancer Symposium (SABCS) 2025, Texas, Amerika Birleşik Devletleri, 9 - 12 Aralık 2025, ss.2028, (Özet Bildiri)
Background: Primary breast lymphoma is an extremely rare malignancy, and its occurrence in male patients is even less common, with
limited published data available. Due to its rarity, the clinicopathological characteristics and prognostic factors in male breast lymphoma
remain poorly understood. Better characterization of this unique patient group may contribute to more tailored diagnostic and therapeutic
approaches. This study aimed to evaluate the clinicopathological features and prognoses of patients diagnosed with male breast lymphoma.
Method: Data for this study were extracted from the Surveillance, Epidemiology, and End Results (SEER) database, covering cases of male
breast lymphoma diagnosed between 2000 and 2021. Demographic, clinicopathological, and survival data were collected and analyzed.
Survival outcomes were assessed using Kaplan-Meier curves with the log-rank test. Results: A total of 138 patients were included in the
study. 86 (62.3%) of the patients were over 65 years of age. The race of 122 (88.4%) patients was white. The disease was detected in the
right and left breast at a similar rate (Right- 48.6%, Left - 47.1%). The most common histopathological types were Diffuse Large B Cell
Lymphoma (39.1%), MALT (mucosa-associated lymphoid tissue) lymphoma (23.9%), and Follicular lymphoma (17.4%), respectively. According
to the Ann Arbor staging system, the valid percentage of Stage 1 disease was 48.8% and the rate of Stage 2 disease was 21.3%. Breast
surgery was performed in 30.4% of the patients, as a valid percentage, the rate of patients who received radiotherapy was 31.2% and the rate
of patients who received chemotherapy was 44.9%. B symptoms were present in 6.7% of the patients. The 5-year and 10-year survival rates
were 71.7% and 55.7%, respectively. In the prognostic evaluation of the factors affecting survival; age (p<0.001), tumor side (p=0.727), race
(p=0.539), origin (p=0.888), presence of B symptom (p=0.778), lymphoma type (p<0.001), stage (p=0.040), breast surgery (p=0.555),
radiotherapy (p=0.033), chemotherapy (p=0.017) were determined. Conclusion: Male breast lymphoma is quite rare and is more common
in the elderly population. Age, type of lymphoma, and tumor stage were identified as prognostic factors. Receiving chemotherapy and
radiotherapy in treatment has a positive effect on prognosis.