Maspin overexpression correlates with increased expression of vascular endothelial growth factors A, C, and D in human ovarian carcinoma


Bolat F., GÜMÜRDÜLÜ D., Erkanli S. , Kayaselcuk F., Zeren H., VARDAR M. A. , et al.

PATHOLOGY RESEARCH AND PRACTICE, cilt.204, ss.379-387, 2008 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 204 Konu: 6
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1016/j.prp.2008.01.011
  • Dergi Adı: PATHOLOGY RESEARCH AND PRACTICE
  • Sayfa Sayısı: ss.379-387

Özet

The vascular endothelial growth factor (VEGF) family, including VEGFA, VEGFC, and VEGFD, plays an essential role in the angiogenesis of both pathologic and nonpathologic conditions. Maspin belongs to the serpin superfamily and has been identified as a tumor suppressor because it inhibits motility, invasion, and angiogenesis. Few studies have compared maspin with VEGF in ovarian carcinoma. Therefore, we investigated the expression and correlation of maspin, VEGFA, VEGFC, and VEGFD with the tumorigenesis of the ovary and clinicopathologic variables.